I think the answer to this one is because of the effect that they have on each other. The other thing is that if you are depressed alcohol can have the effect of depressing your further so with or without antidepressants, they are not a good idea. Your doctor will be able to tell you exactly what the adverse interaction is between any specific medication and alcohol.
In general though, the reason it is often recommended to avoid alcohol while you are on antidepressants and is that alcohol and antidepressants act on the same chemicals in the brain. Naturally, alcohol is likely to counteract the effects of antidepressants. In turn, antidepressants can aggravate the intoxication ability of alcohol. These are some reasons why antidepressants and alcohol consumption should not be mixed with each other.
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